Evolutionary genomics & gene regulation.

Joshua Rest’s lab @ Ecology and Evolution @ Stony Brook University. We use computation, experiments, and natural history to study the evolution of biological systems.

News

Keffy Kehrli describes his thesis in three minutes.

Graduate student Keffy Kehrli has won 3rd place in SBU’s Three Minute Thesis Virtual Competition.
Last updated on May 4, 2020 1 min read

Nature Methods paper on Marine Protist Genetic Tools

We have been developing the tools and methodology for genetically transforming a single-celled marine fungus-like organism known as Aurantiochytrium limacinum ATCC MYA-1381.
Last updated on May 4, 2020 2 min read

Projects

Phylogenetic Gene Expression Meta-Analysis

Does the expression of vertebrate genes evolve under purifying selection? Resolving the regulatory innovation paradox.

Cell to Cell Expression Variation

Does the distribution of protein expression levels vary and evolve? Why?

Functional Genomics of Labyrinthulomycetes.

Developing tools to investigate genes involved in ecologically and evolutionarily interesting labyrinthulomycete traits, including carotenoid biosynthesis and the production of the ectoplasmic network.
Project Video

Meet the Team

Principal Investigator

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Joshua Rest

Associate Professor

Post-docs

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Anbarasu Karthikaichamy

Grad Students

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Alex Gil Gomez

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Keffy Kehrli

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Mariana Rius

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Michael Horowitz

Undergraduate Researchers

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Injun Choi

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Jordan Chee

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Nina Gu

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So Hyun-Park

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Whitney Wong

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Xegfred Lou Quidet

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Zain Ahmed

Alumni

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Kash Bandaralage

Publications

Genetic tool development in marine protists: Emerging model organisms for experimental cell biology

Drahomíra Faktorová, R Ellen R Nisbet, José A Fernández Robledo, Elena Casacuberta, Lisa Sudek, Andrew E Allen, Manuel Ares, Cristina Aresté, Cecilia Balestreri, Adrian C Barbrook

Swimming, gliding, and rolling toward the mainstream: cell biology of marine protists

Jackie L Collier, Joshua S Rest

What makes a kinase promiscuous for inhibitors?

Sonya M Hanson, George Georghiou, Manish K Thakur, W Todd Miller, Joshua S Rest, John D Chodera, Markus A Seeliger
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Widespread ancient whole‐genome duplications in Malpighiales coincide with Eocene global climatic upheaval

Liming Cai, Zhenxiang Xi, André M Amorim, Manickam Sugumaran, Joshua S Rest, Liang Liu, Charles C Davis

Evolution of pathogen response genes associated with increased disease susceptibility during adaptation to an extreme drought in a Brassica rapa plant population

NB O'Hara, SJ Franks, NC Kane, S Tittes, JS Rest
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